Detalhe da pesquisa
1.
Phase 1 study of safety and tolerability of an oral contraceptive containing low-dose ethinyl oestradiol combined with glecaprevir/pibrentasvir treatment in healthy premenopausal women.
J Viral Hepat
; 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38654438
2.
Higher vs Standard Adalimumab Induction Dosing Regimens and Two Maintenance Strategies: Randomized SERENE CD Trial Results.
Gastroenterology
; 162(7): 1876-1890, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35122766
3.
Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results.
Gastroenterology
; 162(7): 1891-1910, 2022 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-35227777
4.
Interdisciplinary model-informed drug development for extending duration of elagolix treatment in patients with uterine fibroids.
Br J Clin Pharmacol
; 88(12): 5257-5268, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35695781
5.
Efficacy and safety of continuing versus withdrawing adalimumab therapy in maintaining remission in patients with non-radiographic axial spondyloarthritis (ABILITY-3): a multicentre, randomised, double-blind study.
Lancet
; 392(10142): 134-144, 2018 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-29961640
6.
Two Phase 3 Trials of Adalimumab for Hidradenitis Suppurativa.
N Engl J Med
; 375(5): 422-34, 2016 Aug 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27518661
7.
Determining the optimal dose of atrasentan by evaluating the exposure-response relationships of albuminuria and bodyweight.
Diabetes Obes Metab
; 20(8): 2019-2022, 2018 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29603851
8.
Veliparib in combination with whole brain radiation therapy in patients with brain metastases: results of a phase 1 study.
J Neurooncol
; 122(2): 409-17, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25682091
9.
Bioequivalence of Elagolix/Estradiol/Norethindrone Acetate Fixed-Dose Combination Product: Phase 1 Results in Healthy Pre- and Postmenopausal Women.
Clin Pharmacol Drug Dev
; 2024 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38593267
10.
Assessing the Impact of Immunogenicity and Improving Prediction of Trough Concentrations: Population Pharmacokinetic Modeling of Adalimumab in Patients with Crohn's Disease and Ulcerative Colitis.
Clin Pharmacokinet
; 62(4): 623-634, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36905528
11.
Assessment of Drug-Drug Interaction Risk Between Intravenous Fentanyl and the Glecaprevir/Pibrentasvir Combination Regimen in Hepatitis C Patients Using Physiologically Based Pharmacokinetic Modeling and Simulations.
Infect Dis Ther
; 12(8): 2057-2070, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37470926
12.
Therapeutic Development in Polyarticular Course Juvenile Idiopathic Arthritis: Extrapolation, Dose Selection, and Clinical Trial Design.
Arthritis Rheumatol
; 75(10): 1856-1866, 2023 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37067688
13.
Effects of elagolix on the pharmacokinetics of omeprazole and its metabolites in healthy premenopausal women.
Clin Transl Sci
; 15(5): 1269-1280, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35137535
14.
Population Pharmacokinetics of Elagolix in Combination with Low-Dose Estradiol/Norethindrone Acetate in Women with Uterine Fibroids.
Clin Pharmacokinet
; 61(4): 577-587, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34878624
15.
Bridging Fixed Dose to Body Weight-based Regimen of Adalimumab in Paediatric Ulcerative Colitis Using a Pharmacometric Modelling Approach: Case Study with the Phase 3 ENVISION I Trial.
J Crohns Colitis
; 16(10): 1551-1561, 2022 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35526272
16.
Drug-Drug Interaction Studies of Elagolix with Oral and Transdermal Low-Dose Hormonal Add-Back Therapy.
Clin Pharmacokinet
; 60(1): 133-143, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32696440
17.
Validation of a quantitative systems pharmacology model of calcium homeostasis using elagolix Phase 3 clinical trial data in women with endometriosis.
Clin Transl Sci
; 14(4): 1611-1619, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33963686
18.
Integrating real-world data and modeling to project changes in femoral neck bone mineral density and fracture risk in premenopausal women.
Clin Transl Sci
; 14(4): 1452-1463, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33650259
19.
Comparative Bioavailability of Two Formulations of Biopharmaceutical Classification System (BCS) Class IV Drugs: A Case Study of Lopinavir/Ritonavir.
J Pharm Sci
; 110(12): 3963-3968, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34530003
20.
Efficacy and safety of adalimumab in paediatric patients with moderate-to-severe ulcerative colitis (ENVISION I): a randomised, controlled, phase 3 study.
Lancet Gastroenterol Hepatol
; 6(8): 616-627, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34153231